منابع مشابه
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.
The functional potential of hematopoietic stem cells (HSCs) declines during aging, and in doing so, significantly contributes to hematopoietic pathophysiology in the elderly. To explore the relationship between age-associated HSC decline and the epigenome, we examined global DNA methylation of HSCs during ontogeny in combination with functional analysis. Although the DNA methylome is generally ...
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The notion of complex energy landscape underpins the intriguing dynamical behaviors in many complex systems ranging from polymers, to brain activity, to social networks and glass transitions. The spin glass state found in dilute magnetic alloys has been an exceptionally convenient laboratory frame for studying complex dynamics resulting from a hierarchical energy landscape with rugged funnels. ...
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Senescence is characterized by the decline in the ability to cope with stress. Hormesis regulation of opposing biological effects of low and high dosages, can determine longevity, and disease vulnerability at appropriate doses. Regulation of age-related changes in micro RNA opens new areas of therapeutic targets. Micro RNA downregulates stress response pathways with age establishing vulnerabili...
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The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...
متن کاملAging in a free-energy landscape model for glassy relaxation.
The aging properties of a simple free-energy landscape model for the primary relaxation in supercooled liquids are investigated. The intermediate scattering function and the rotational correlation functions are calculated for the generic situation of a quench from a high temperature to below the glass transition temperature. It is found that the reequilibration of molecular orientations takes l...
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ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2019
ISSN: 2399-5300
DOI: 10.1093/geroni/igz038.755